Now let’s talk about safety.

Overall, 1 of every 550 patients started on opioid therapy died of opioid-related causes a median of 2.6 years after the first opioid prescription; the proportion was as high as 1 in 32 among patients receiving doses of 200 MME or higher.5 We know of no other medication routinely used for a nonfatal condition that kills patients so frequently.

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